Division of Transdimensional Life Imaging, Institute for Open and Transdisciplinary Research Initiatives, Osaka University

The Transdimensional Life Imaging Division develops trans-scale imaging methods to observe at a wide scale hierarchy from micro (molecules and cells) to macro (tissues and individuals) to understand living systems.

CONCEPT

To date, bioimaging research has led to numerous important discoveries. On the other hand, traditional bioimaging has been specialized to micro or macro spatial scales, often producing conflicting results between imaging at the cellular level and imaging of higher-order macroscopic systems. This was due to the large scale gap that exists between micro and macroscopic systems, ranging from three to six orders of magnitude in terms of the number of cells. Resolving this micro-macro paradox and approaching a more comprehensive understanding of life phenomena is an important issue for the development of various life science research fields, including biology as well as medicine, pharmacology, and agriculture. Therefore, the development of trans-scale imaging technology that enables measurement and analysis at a wide range of scale hierarchies from micro to macro scales has been desired.

We will integrate Osaka University's world-leading technologies including single molecule fluorescence imaging, whole tissue/body imaging, fluorescence and bioluminescence probe technology, image analysis technology, and big data analysis technology to develop theone-and-only bioimaging device that can "see both the trees and the forest" in the same specimen. We intend to open this device to the public as a shared-use device and promote research that contributes to the formation of a healthy and long-lived society.

< New paper now available on eLife >
A paper on the transcale imaging system AMATERAS-2 has been opend on eLife. We have developed a technique that enables 3D fluorescence observation of cell distribution and its temporal changes in centimeter-wide tissues and embryos. The current version is the Reviewed Preprint and we will upload the revised version soon.
https://doi.org/10.7554/elife.93633.1

< New paper now available on Biophysics and Physicobiology >
A review article on our research has been opend on Biophysics and Physicobiology. The article intensively discussed the "strength in numbers" achieved by our large-scale optical imaging technology.
https://doi.org/10.2142/biophysico.bppb-v21.s017

Promotional video available.
A promotional video for AMATERAS, developed by our research division is now available.
　　　　　

　　　　　

Call for joint reseach proposal
We are looking for collaborations using the trans-scale scope AMATERAS developed by our research division. For details, please visit the website of "Singularity Biology".
singularity-bio.jp/amateras/

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